Journal
RSC ADVANCES
Volume 4, Issue 46, Pages 24311-24315Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra02690j
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Funding
- Department of Science and Technology, Government of India [SR/FT/CS-013/2009]
- University Grants Commission, Government of India
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The catalytic efficacy of the smallest organocatalyst, L-proline hydrazide, prepared from a cheaply available natural amino acid, such as L-proline, was studied for the direct asymmetric aldol reaction of various ketones with aromatic aldehydes at room temperature in the presence of several acid additives. A loading of 10 mol% of catalyst 1 and p-toluenesulphonic acid as an additive was employed in this reaction, and good yields (up to 99%) with high anti/syn diastereoselectivities (up to 95 : 5) and enantioselectivities (up to >99.9%) were achieved in aqueous media.
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