Journal
RSC ADVANCES
Volume 4, Issue 15, Pages 7380-7388Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra44568b
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Funding
- UGC, New Delhi
- CSIR, New Delhi [02(0110)/12/EMR-II]
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An efficient and straightforward L-proline catalyzed one-pot synthesis of a series of biologically relevant gem-(beta-dicarbonyl)arylmethanes has been developed via a three-component reaction between indoles, aldehydes and C-H activated acids by grinding them together under solvent-free conditions at room temperature. Mild reaction conditions, high atom-economy, good yields, and eco-friendliness are some of the salient features of the present protocol.
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