4.6 Article

An oxidative cleavage-based ratiometric fluorescent probe for hypochlorous acid detection and imaging

Journal

RSC ADVANCES
Volume 4, Issue 104, Pages 59961-59964

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra09611h

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Funding

  1. National Basic Research Program of China [2011CB933700]
  2. National Natural Science Foundation of China [21228702, 21302187, 21205120]

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A new fluorescent molecule of an imidazole derivative was synthesized through simple cyclization of a hetero-aromatic compound and successfully applied for the rapid and ratiometric sensing of HOCl with high sensitivity and selectivity. It has also been demonstrated for the bioimaging of HOCl using A549 cells.

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