Journal
RSC ADVANCES
Volume 4, Issue 103, Pages 59211-59217Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra11181h
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Funding
- National Natural Science Foundation of China [21374133, 21276285, 21104096]
- Hunan Provincial Natural Science Foundation of China [12JJ4014]
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In this work, carboxymethyl dextran (CMD), a polysaccharidic dextran derivative with well-known biocompatibility and biodegradability, was used to modify curcumin-loaded liposomes for improving the anticancer efficacy of curcumin. The CMDylated curcumin-loaded liposomes (CMD-Cur-Lip) were successfully prepared and characterized in comparison with unmodified and two PEGylated curcumin-loaded liposomes. The results showed that: (1) the encapsulation efficiency of curcumin in the liposomes was improved after being modified with CMD; (2) all the curcumin-loaded liposomes displayed controlled release characteristics; (3) the CMD-Cur-Lip demonstrated improved cell cytotoxicity against cancer cells, as compared to other liposomal formulations and free curcumin; (4) CMD-Cur-Lip exhibited the highest cellular uptake as compared to other liposomal formulations.
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