Journal
RSC ADVANCES
Volume 4, Issue 104, Pages 59965-59969Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra12007h
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Funding
- National Natural Science Foundation of China [81201195, 81172601]
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The bisphosphonate group of alendronate was found to possess high binding affinity to ceria nanoparticles (CNPs). Using alendronate as an anchor, functional molecules could be easily grafted onto CNPs leading to enhanced enzyme mimetic activity, reduced cytotoxicity, improved stability, prolonged blood circulation, and decreased liver and especially spleen accumulation of the nanoparticles.
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