Journal
RSC ADVANCES
Volume 4, Issue 22, Pages 11073-11079Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra47796g
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Funding
- Naito Foundation
- Cooperative Research Program of Medical Mycology Research Center, Chiba University
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid for Scientific Research [25460115, 25670043] Funding Source: KAKEN
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Two new acetylenic fatty acid derivatives possessing a taurine amide residue, taurospongins B (1) and C (2), have been isolated from an Okinawan marine sponge of the family Spongiidae. The gross structures of 1 and 2 were elucidated on the basis of their spectral data, especially 2D NMR and FABMS/MS data. The absolute configurations for 1 and 2 were established by chemical means. Taurospongin C (2) showed inhibitory activity against Cryptococcus neoformans.
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