Journal
RSC ADVANCES
Volume 4, Issue 49, Pages 25790-25794Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra03725a
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Funding
- National Natural Science Foundation of China [21276251]
- Ministry of Human Resources and Social Security of PRC
- Chinese Academy of Science
- State Key Laboratory of Fine Chemicals of China [KF1105]
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Hydrogen sulfide (H2S) is an endothelial gasotransmitter which has been extensively studied recently in various physiological processes. H2S can induce lysosomal membrane destabilization leading to an autophagic event of precipitation apoptosis coupled with calpain activation, thus ensuring cellular demise. In this study, we developed a lysosome-targetable fluorescent probe for the recognition of H2S with considerable fluorescence enhancement. Through introducing a lysosome-targetable group 4-(2aminoethyl)-morpholine into the H2S probe N-imide termus of 4-azide-1,8-naphthalimide, the new compound Lyso-AFP can recognize H2S in lysosomes. This probe emerges as a more biocompatible analysis tool with low poison by-product than reported H2S fluorescent probes.
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