Journal
RSC ADVANCES
Volume 4, Issue 83, Pages 44197-44202Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra09006c
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Funding
- National Science Fund for Distinguished Young Scholars [51225403]
- Hunan Provincial Natural Science Fund for Innovative Research Groups
- Specialized Research Fund for the Doctoral Program of Higher Education [20120162110079]
- Fundamental Research Funds for the Central Universities of Central South University [2014zzts274]
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Natural halloysite nanotubes (HNTs) modified with 3-aminopropyltriethoxysilane were used as an aspirin carrier. The structure, drug loading and release profiles of samples were characterized by X-ray diffraction (XRD), thermogravimetry-differential scanning calorimetry (TG-DSC), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and UV-spectrophotometry. The Higuchi model Q = kt(0.5) was employed to analyze the dissolution data in detail. The results indicated that the modification of HNTs could improve the amount of aspirin from 3.84 to 11.98 wt%. The physical state of aspirin was nanocrystalline and amorphous affected by the confined space of HNTs, which significantly enhanced the dissolution rate created by a burst release within the first hour. The linearity of the Higuchi equation indicated that the aspirin release mechanism for modified HNTs was fitted to Fick's diffusion and the dissolution rate was slower than that of natural HNTs. The as-synthesized N-HNTs could have interesting potential application in drug carrier systems.
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