4.6 Article

PEGylated aza-BODIPY derivatives as NIR probes for cellular imaging

Journal

RSC ADVANCES
Volume 4, Issue 5, Pages 2306-2309

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra46235h

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Funding

  1. Spanish Ministry of Science and Innovation [CTQ2010-20303]
  2. Economy, Innovation and Science Council of the Andalusian Regional Government [FQM-017]

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Neutral water-soluble aza-dipyrromethene boron difluoride (azaBODIPY) derivatives are synthesized for biological imaging applications. Aqueous solubility is increased by optimizing the synthetic conditions to obtain aza-BODIPYs with several tetraethyleneglycol groups. Their spectral properties and assays performed on cultured cells, demonstrate the potential of these compounds as near-infrared (NIR) emitting fluorescent probes.

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