Journal
RSC ADVANCES
Volume 3, Issue 47, Pages 24853-24857Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra44125c
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Funding
- National Science Foundation of China [21205097]
- National Key Basic Research Program of China (973 Program) [2013CB127804]
- Institute for Clean Energy & Advanced Materials (Southwest University, Chongqing, China)
- Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies (Chongqing, China)
- Southwest University (Chongqing, China) [SWU111071]
- Chongqing Engineering Research Center for Rapid diagnosis of Dread Disease (Chongqing, China)
- Chongqing development and reform commission (Chongqing, China)
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Multifunctional graphene quantum dots (GQDs) conjugated layered protonated titanate (LPT) nanoflowers have been developed as a promising system for fluorescence imaging and targeted drug delivery. The layered structure of the titanate nanoflowers provides a high specific area for loading drugs. The negatively charged nanocarrier shows a high loading capacity for doxorubicin (DOX). The fluorescence of GQDs reveals the intracellular localization of nanocarriers, suggesting that the uptake is via active endocytosis. Anti-HER2 labelling not only enables rapid uptake into HER2-overexpressing cancer cells, but also improves the nuclear accumulation of DOX. While the drug-free nanocarriers are highly biocompatible for up to 200 mu gmL(-1), the DOX loaded nanocarriers are more potent than free DOX in anticancer therapy. It is demonstrated that the anti-HER2-GQD-LPT system is a promising platform for simultaneous cancer imaging and anticancer therapeutics.
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