Journal
RSC ADVANCES
Volume 3, Issue 19, Pages 6693-6716Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra22891f
Keywords
-
Categories
Funding
- Ukrainian National Academy of Sciences [02-03-12]
- IKERBASQUE
- Basque Foundation for Science
Ask authors/readers for more resources
This review article surveys recent achievements in the preparation and biological properties evaluation of fluorinated aminophosphonates and aminophosphonic acids. Recently, in view of various important biological applications of the fluorinated aminophosphonic acid derivatives, the development of suitable synthetic methodologies for their preparation in racemic and in optically pure form has been a topic of great interest. Considerable progress has been made in asymmetric synthesis of fluorinated acyclic aminophosphonates and aminophosphonic acids using catalytic enantioselective reduction of fluorinated alpha-iminophosphonates, catalytic enantioselective addition of alkyl phosphites to fluorinated imines, and diastereoselective addition of alkyl phosphites to chiral fluorinated imines. A new efficient access to CF3-substituted cyclic alpha-aminophosphonates has been developed based on metal-catalyzed carbene transfer reactions with diethyl 1-diazo-2,2,2-trifluoroethylphosphonate. New processes, e. g. enantioselective alkynylation and nucleophilic aromatic substitution involving fluorinated substrates are also considered.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available