Journal
RSC ADVANCES
Volume 3, Issue 48, Pages 25550-25564Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra45219k
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Funding
- Engineering and Physical Sciences Research Council [1085932] Funding Source: researchfish
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Photodynamic therapy (PDT) requires a photosensitizing agent, which can undergo visible light activation, yielding reactive oxygen species and/or radical species. The key physical properties and desirable attributes of established PDT photosensitizer agents are discussed, together with a consideration of the role that photoactive metal coordination complexes may have in the future design of such agents. A number of classes of metal complex are included with a focus upon their ability to generate singlet oxygen, and prior indications of biological utility, compatibility and cytotoxicity through cellular imaging work and DNA binding behaviour.
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