Journal
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
Volume 4, Issue 4, Pages 377-389Publisher
WILEY
DOI: 10.1002/wdev.185
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Funding
- NSF [IOS-1355181]
- NIH [R01NS054739, T32GM008216]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1355181] Funding Source: National Science Foundation
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In bilaterally symmetric animals, the precise assembly of neural circuitry at the midline is essential for coordination of the left and right sides of the body. Commissural axons must first be directed across the midline and then be prevented from re-crossing in order to ensure proper midline connectivity. Here, we review the attractants and repellents that direct axonal navigation at the ventral midline and the receptors on commissural neurons through which they signal. In addition, we discuss the mechanisms that commissural axons use to switch their responsiveness to midline-derived cues, so that they are initially responsive to midline attractants and subsequently responsive to midline repellents. (C) 2015 Wiley Periodicals, Inc.
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