Journal
RSC ADVANCES
Volume 3, Issue 18, Pages 6545-6552Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra40650d
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Funding
- National Natural Science Foundation of China [21272280]
- Strategic Cooperation Program between Guangdong Province
- Chinese Academy of Sciences [2009B091300125]
- Core Technology Program for Strategy Emerging Industries of Guangdong Province [2011A081401002]
- National Significant New Drugs Development [2011ZX09202-101-07]
- Science and Technology Program of Guangzhou City [2012J4300097]
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A novel and convenient bio-based protocol for the preparation of N-aryl amino acid derivatives from (-)-methyl-3-dehydroshikimate and amino acid esters via tandem cross-coupling and aromatization reactions has been developed. Various N-aryl amino acid esters were synthesized in moderate to high yields under mild and metal-free conditions without using aryl halides.
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