One-pot synthesis of carbon-decorated FePt nanoparticles and their application for label-free electrochemical impedance sensing of DNA hybridization

Highly monodispersive FePt nanoparticles (NPs) assembled on carbon nanotubes (CNTs) or graphene oxide (GO) surfaces to form carbon-decorated FePt nanocomposites (FePt-CNTs and FePt-GO) were successfully obtained via a one-pot modified polyol protocol. Using the as-prepared nanocomposites, a novel, ultra-high-resolution electrochemical impedance DNA biosensor for the enhanced detection of the PML-RARA fusion gene in acute promyelocytic leukemia was obtained. The detection limit is up to 10(-13) mol L-1 for FePt-CNT-modified electrodes and 10(-14) mol L-1 for FePt-GO-modified electrodes, respectively. This work proposed a simple polyol strategy to synthesize carbon-decorated FePt nanocomposites and opened up a new direction in the application of FePt for biosensing.