Journal
RSC ADVANCES
Volume 3, Issue 43, Pages 20726-20731Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra43656j
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Funding
- 973 Program of China [2010CB833804]
- 863 Program of China [2013AA092901, 2012AA092104, 2011AA09070106]
- Innovation and Research Foundation of Ocean University of China [201261002]
- Key Laboratory of Marine Drug (Ocean University of China), Ministry of Education [KLMD (OUC)201302]
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Seven new alpha-pyrones, nocapyrones H-N (1-7) were isolated from the marine-derived actinomycete strain, Nocardiopsis dassonvillei subsp. dassonvillei XG-8-1. The new structures 1-7 were determined by spectroscopic analysis, CD spectra, ECD quantum chemical calculations and the modified Mosher's method. Compounds 1, 2 and 6 showed inhibitory effects on quorum sensing (QS) controlled gene expression in Chromobacterium violaceum CV026 and Pseudomonas aeruginosa QSIS-lasl biosensors at a concentration of 100 mu g mL(-1), respectively. This is the first report of inhibition of alpha-pyrones on QS controlled gene expression in pathogenic bacteria.
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