Journal
RSC ADVANCES
Volume 3, Issue 25, Pages 9681-9686Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra40200b
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Funding
- Key National Science and Technology Projects on Key New Drug Creation and Manufacturing [2012ZX09506001-001]
- Centre for Functional Photonics at City University of Hong Kong
- Natural Science Foundation of Shaanxi Province [2012JM2003]
- Shaanxi Education Commission [12JK0628]
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Composite Fe3O4/Au nanoparticles are attracting considerable interest in nanomedicine due to their unique physical and chemical properties. However, successful applications of these particles are generally limited by their severe aggregation due to their ionic instability under physiological conditions. Here, by harnessing the steric stabilization and chemical ligand synergistic cooperation, we demonstrated that composite Fe3O4/Au nanoparticles exhibited desirable colloidal stability, dispersity and functionalities in a wide range of pH values, rendering visual and specific detection of biomolecules of interest without using complex fluid handling and detection instruments. We envision that these novel composite nanoparticles might serve as ideal probes for real time, point of care diagnostics and therapy in resource-poor settings.
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