Journal
RSC ADVANCES
Volume 3, Issue 41, Pages 18923-18930Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra43889a
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Funding
- University Grant Commission (UGC), New Delhi
- CSIR, New Delhi
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A simple and convenient strategy is described for the synthesis of imidazo[1,2-a]pyridines via inexpensive copper-catalyzed tandem imine formation and intramolecular aerobic oxidative C-H bond amination/cyclizations. An array of imidazo[1,2-a]pyridines were prepared by the reaction of readily available acetophenones and 2-aminopyridines in good to excellent yields (48-92%). The scope of the method was validated by a single step synthesis of Zolimidine, a drug used for peptic ulcers, in 61% yield.
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