Journal
RSC ADVANCES
Volume 3, Issue 44, Pages 22560-22571Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra43340d
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- Agence Nationale de la Recherche CaBMT
- Ministere de l'Enseignement Superieur
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Fluorescent oligomannosides are important tools for the evaluation of mannosyl transferase activities and selectivities. In a project dealing with Candida albicans beta-mannosyl transferases, three mantyl tagged alpha (1 -> 2) oligomannosides were prepared by different ways: using all ester strategy compatible with the presence of an azido group suitable for direct click chemistry; and alternatively using the more classic benzyl protecting groups. Although more elegant, the all ester strategy has shown important limitations: reduced reactivity of mannosyl donors, and 3 -> 2 ester migration. Preliminary enzymatic studies have shown that the synthetic oligomannosides are efficient substrate of b-mannosyl transferases.
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