4.6 Article

Generation of diverse isoquinoline N-oxides in an aqueous system

Journal

RSC ADVANCES
Volume 3, Issue 33, Pages 13626-13629

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra42730g

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Funding

  1. National Natural Science Foundation of China [21032007, 21172038]

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4-Halo isoquinoline N-oxides could be synthesized efficiently via the electrophilic cyclization of 2-alkynylbenzaldoximes, involving the in situ generation of the halonium ion in water. The one-pot cyclization-Suzuki reaction in an aqueous system afforded the functionalized isoquinoline N-oxides in good yields.

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