4.6 Article

Silver nanoshells as tri-mode bactericidal agents integrating long term antibacterial, photohyperthermia and triggered Ag+ release capabilities

Journal

RSC ADVANCES
Volume 3, Issue 27, Pages 10632-10638

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra40417j

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Funding

  1. National Natural Science Foundation of China [21074051, 51173077]
  2. Fundamental Research Funds for the Central Universities [1085021309]
  3. Nature Science Foundation of Jiangsu Province [BK2012531]
  4. Nanjing Medical Science and Technique Development Foundation [2012001]

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Novel polymer-silver hybrid core-shell nanoparticles (SNSs) which showed long term bacteriostatic, photohyperthermia induced bactericidal and triggered Ag+ release abilities were reported. Both gram-negative (GN) and gram-positive (GP) bacteria can be effectively killed by photothermolysis therapy. The Ag+ release triggered by illumination provides a sustained release of Ag+, which offers long term antibacterial ability under normal conditions.

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