Journal
RSC ADVANCES
Volume 3, Issue 6, Pages 1660-1665Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ra23073a
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In this study, we used graphene, a one-atom thick sheet of carbon atoms, to modify the surfaces of existing implant materials to enhance both bio-and hemo-compatibility. This novel effort meets all functional criteria for a biomedical implant coating as it is chemically inert, atomically smooth and highly durable, with the potential for greatly enhancing the effectiveness of such implants. Specifically, graphene coatings on nitinol, a widely used implant and stent material, showed that graphene coated nitinol (Gr-NiTi) supports excellent smooth muscle and endothelial cell growth leading to better cell proliferation. The authors further determined that the serum albumin adsorption on Gr-NiTi is greater than that of fibrinogen, which is an important and well understood criterion for promoting a lower thrombosis rate. These hemo- and biocompatible properties, along with high strength, chemical inertness and durability provide graphene with an edge over most antithrombogenic coatings for biomedical implants and devices.
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