Journal
RSC ADVANCES
Volume 3, Issue 43, Pages 20209-20218Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra42923g
Keywords
-
Categories
Funding
- DGAPA UNAM [PAPIIT-IN209812]
- projects SEP-CONACyT [167430, 167491]
Ask authors/readers for more resources
The peroxyl radical scavenging activity of piceatannol has been studied in aqueous and lipid solutions, using the density functional theory, and compared to that of its structural analogue resveratrol. The following mechanisms of reaction have been considered: hydrogen transfer (HT), single electron transfer (SET) and radical adduct formation (RAF). Piceatannol was found to be a better peroxyl scavenger than resveratrol, regardless of the polarity of the environment. In aqueous solution, at physiological pH, its higher activity is directly related to its acidity. The further reactions of the phenoxyl radical products (yielded by the reactions of (OOH)-O-center dot with piceatannol and resveratrol) with the superoxide radical anion have also been investigated. It was found that in the aqueous phase, at physiological pH, resveratrol and piceatannol can be efficiently regenerated after scavenging two free radicals ((OOH)-O-center dot and O-center dot(2)-). This suggests that these compounds have the ability of scavenging more than 2 radical equivalents, under such conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available