4.6 Article

Highly enantioselective hydrophosphonylation of imines catalyzed by SPINOL-phosphoric acid

Journal

RSC ADVANCES
Volume 3, Issue 29, Pages 11895-11901

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra40958a

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Funding

  1. National Natural Foundation of China [21272202, J1210042]
  2. Fundamental Research Funds for the Central Universities

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Chiral SPINOL-phosphoric acid is a highly enantioselective organocatalyst for asymmetric hydrophosphonylation of cinnamaldehyde-derived aldimines with diethyl phosphite at room temperature, affording a-amino phosphonates in 85-98% yields and 80-98% ee.

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