4.6 Article

An efficient synthetic approach for N-C bond formation from (S)-amino acids: an easy access to cis-2,5disubstituted chiral piperazines

Journal

RSC ADVANCES
Volume 3, Issue 40, Pages 18332-18338

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra42309c

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Funding

  1. DST, New Delhi, India
  2. CSIR, India

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An efficient synthetic strategy is described for the construction of amino acids derived enantiomerically pure cis-2,5-disubstituted chiral piperazines. Cu-catalyzed spontaneous regioselective ring opening and ring closing of non-activated N-tosyl aziridines as well as Pd-mediated N-C bond formation from N-tosyl halogenated amino-derivatives are the key steps for accessing disubstituted piperazines.

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