Journal
RSC ADVANCES
Volume 3, Issue 4, Pages 1025-1028Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ra22901c
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Funding
- National Natural Science Foundation of China [21072225, 21172258, 91127039]
- Fundamental Research Funds for Central Universities
- Research funds of the Renmin University of China [11XNL011]
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An efficient protocol for the direct synthesis of 8-arylated tetrahydroquinolines via Pd-catalyzed ortho-arylation of aryl ureas with aryl iodides was developed. The reaction proceeded smoothly in water under ligand-free and surfactant-free conditions, providing the desired products in high yields with remarkable functional group tolerance.
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