Journal
RSC ADVANCES
Volume 2, Issue 29, Pages 11078-11083Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ra21736h
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Funding
- Research Committee of Hong Kong Baptist University [FRG2/11-12/121]
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By incorporating 4-aminoantipyrine moiety onto 8-aminoquinoline with a suitable spacer, a highly selective and sensitive fluorescent Zn2+ sensor, QPA, was designed and constructed. In 25% ACN-HEPES buffer pH 7.0 solution, QPA exhibited 10.6-fold fluorescence enhancement at 500 nm upon addition of Zn2+. The limit of detection (LOD) was calculated to be 1.3 x 10(-7) M according to fluorescence titration. The 1 : 1 binding mode of the metal complex was established by combined UV-vis, fluorescence and HRMS spectroscopic method. The membrane permeability of QPA to living cells and bioimaging of Zn2+ are demonstrated.
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