4.6 Article

Lipase-catalyzed regioselective acylation of sugar in microreactors

Journal

RSC ADVANCES
Volume 2, Issue 7, Pages 2663-2665

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ra01112c

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Funding

  1. Natural Science Foundation of Zhejiang Province [Y4080126]
  2. Science and Technology Research Program of Zhejiang Province [2008C12084]
  3. Natural Science Foundation of Zhejiang University of Technology [116004029]

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The highly regioselective synthesis of sugar 6-monoesters with sugar and vinyl carboxylate in a flow microreactor using Lipozyme TL IM from Thermomyces lanuginosus as a catalyst has been developed. The important features of this method include mild reaction conditions, short reaction times (30 min), high yields and high regioselectivities.

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