Journal
RSC ADVANCES
Volume 2, Issue 4, Pages 1524-1532Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ra00701g
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Categories
Funding
- CNPq
- CAPES
- FAPDF
- INCT-Catalysis
- Finatec
- DPP-UnB
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The present manuscript describes the synthesis of two novel 2,1,3-benzothiadiazole (BTD) derivatives containing an excited state intramolecular proton transfer (ESIPT) site. Photophysical properties, X-ray analysis, ESIPT and intramolecular charge-transfer (ICT) of these novel fluorescent monosubstituted BTD derivatives were investigated. It is also shown that ESIPT and ICT can take place concomitantly. Theoretical calculations (ab initio and DFT) corroborate the high stability of these derivatives in the excited state due to efficient ESIPT and ICT processes. Also, the optimized calculated geometries of these new structures allowed a better understanding of the different behaviour of the dyes in a wide pH range (1-13). Finally, the new compounds exhibit impressive cellular selectivity and stain only mitochondria in different cell lines and are far better than the commercially available MitoTracker-red.
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