4.6 Article

The Au(III)-catalyzed coupling reactions between alcohols and N-heterocycles via C-H bond activation

Journal

RSC ADVANCES
Volume 2, Issue 28, Pages 10496-10498

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ra22120a

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Funding

  1. National Natural Science Foundation of China [20832001, 20972065, 21074054, 21172106]
  2. National Basic Research Program of China [2010CB923303]

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A novel and highly efficient dehydrogenative C-C coupling between sp(3) C-H and sp(2) C-H bonds catalyzed by gold has been developed using environmentally benign tert-butyl hydroperoxide as oxidant. This new methodology provides a facile access to acylate N-heterocycles.

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