Synthesis of the novel trimeric benzamides-potential inhibitors of protein-protein interactions

The synthesis of the family of new non-natural trimeric oligobenzamides (potential inhibitors of protein-protein interactions) bearing the following groups (R = isobutyl, isopropyl, CH2CONH2, (CH2)(4)NH2, benzyl) that mimic different amino acid residues (leucine, valine, asparagine, lysine, phenylalanine) was accomplished through an iterative (n + 1) elongation approach that includes reduction of the NO2-group (Pd/C, H-2) and subsequent amide coupling in the presence of Mukaiyama's reagent.