Journal
RSC ADVANCES
Volume 2, Issue 32, Pages 12263-12268Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ra21688d
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Funding
- National Science Foundation of China [21101140, 31100688, 51102215]
- Zhejiang Provincial Natural Science Foundation of China [Y4110025]
- Zhejiang Qianjiang Talent Project [2012R10062]
- Foundation of Science and Technology Committee of Gansu [1102NKDA033]
- International Science and Technology Cooperation Program of Gansu [1104WCGA185]
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Up-conversion nanoparticles (UCNPs) that emit high-energy photons upon excitation by low-energy near-infrared (NIR) radiation are emerging as new optical nanoprobes useful in biomedicine. Herein, the one pot facile synthesis of mesoporous silica-coated NaYF4:Yb/Er nanoparticles has been achieved successfully. The as-prepared product was characterized by X-ray power diffraction (XRD), transmission electron microscopy (TEM) and Brunauer-Emmet-Teller (BET) surface area analyses, respectively. The resulting nanoparticles with a BET area of 800 m(2) g(-1) and an average pore size of 2.6 nm were spherical, highly monodispersed and stable in an aqueous system. Furthermore, the NaYF4:Yb/Er@mesoporous silica nanoparticles also displayed good biocompatibility and could be used for bio-labeling or bio-imaging. Additionally, the results of preliminary photodynamic therapy (PDT) of cancer cells indicated the NaYF4:Yb/Er@mesoporous silica nanoparticles could be used as important photosensitizer carriers for tumor therapy.
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