Journal
RSC ADVANCES
Volume 1, Issue 5, Pages 758-760Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ra00377a
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Funding
- Grants-in-Aid for Scientific Research [10J01204, 22750092, 21106002] Funding Source: KAKEN
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Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.
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