Journal
PAIN PRACTICE
Volume 14, Issue 1, Pages 43-51Publisher
WILEY-BLACKWELL
DOI: 10.1111/papr.12083
Keywords
pancreatic cancer; celiac plexus block; pain management; meta-analysis; systematic review
Categories
Funding
- Science and technology and social development project of Guangdong Province [2012B031800030]
Ask authors/readers for more resources
Pancreatic ductal adenocarcinoma has a high rate of neural invasion (80 to 100%) and can be associated with moderate to severe pain in pancreatic cancer. Treatment of pain with celiac plexus blockage (CPB) combined with the three-step ladder utilization of pharmaceutical analgesics following WHO guidelines is used, but the evidence in randomized controlled trials is inconsistent. This meta-analysis identified and compared seven randomized control trials of pain relief from pancreatic cancer, by treatment with medical management alone to celiac plexus blockade with medical management. While no evidence of potential publication bias was detected, group size and statistical power may account for some of the inconsistent conclusions. The combined CPB groups had a significantly lower pain score at 4weeks, but significance was not maintained at 8weeks. The combined CPB groups required significantly less drug use compared to the combined control groups treated with pharmaceutical analgesics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available