Journal
ORGANOGENESIS
Volume 10, Issue 1, Pages 108-125Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/org.27483
Keywords
nodal cilia; primary cilia; congenital heart diseases; signaling networks; heart development; stem cells; cardiomyogenesis; heterotaxy
Funding
- Lundbeck Foundation
- Novo Nordisk Foundation
- Danish Council for Independent Research, Nordforsk
- Danish Cancer Society
- Danish Heart Association
- University of Copenhagen, Denmark
- Lundbeck Foundation [R54-2010-5375] Funding Source: researchfish
- Novo Nordisk Fonden [NNF12OC0001790] Funding Source: researchfish
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Primary cilia are unique sensory organelles that coordinate a wide variety of different signaling pathways to control cellular processes during development and in tissue homeostasis. Defects in function or assembly of these antenna-like structures are therefore associated with a broad range of developmental disorders and diseases called ciliopathies. Recent studies have indicated a major role of different populations of cilia, including nodal and cardiac primary cilia, in coordinating heart development, and defects in these cilia are associated with congenital heart disease. Here, we present an overview of the role of nodal and cardiac primary cilia in heart development.
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