Journal
ORGANOGENESIS
Volume 6, Issue 1, Pages 15-23Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/org.6.1.10226
Keywords
adipogenesis; chromatin; histone; DNA methylation; transcription; preadipocyte; commitment; differentiation; epigenetics
Funding
- Spanish Ministry of Science and Innovation (MICINN) [BFU2006-14251/BMC, SAF2006-07382]
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The transcriptional cascade governing adipogenesis has been thoroughly examined throughout the years. Transcription factors PPAR gamma and C/EBP alpha are universally recognized as the master regulators of adipocyte differentiation and together they direct the establishment of the gene expression pattern of mature adipose cells. However, this familiar landscape has been considerably broadened in recent years by the identification of novel factors that participate in the regulation of adipogenesis, either favoring or inhibiting it, through their effects on chromatin. Epigenetic signals and chromatin-modifying proteins contribute to adipogenesis and, through regulation of the phenotypic maintenance of the mature adipocytes, to the control of metabolism. In this review we intend to summarize the recently described epigenetic events that participate in adipogenesis and their connections with the main factors that constitute the classical transcriptional cascade.
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