Journal
ORGANOGENESIS
Volume 6, Issue 3, Pages 141-150Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/org.6.3.12039
Keywords
salamander; frog; intramembranous bone; endochondral bone; limb regeneration; critical size defect; scaffolds; growth factors
Funding
- W.M. Keck Foundation
- U.S. Army Research Office [W911NF07-10176]
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The ability to regenerate bone across a critical size defect would be a marked clinical advance over current methods for dealing with such structural gaps. Here, we briefly review the development of limb bones and the mandible, the regeneration of urodele limbs after amputation, and present evidence that urodele and anuran amphibians represent a valuable research model for the study of segment defect regeneration in both limb bones and mandible.
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