Journal
ORGANOGENESIS
Volume 6, Issue 1, Pages 1-10Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/org.6.1.10427
Keywords
endothelial cell migration; endothelial cell dysfunction; endorepellin; endostatin; endothelial-mesenchymal transition; cell reprogramming
Funding
- NIH [DK54602, DK052783, DK45462]
- Westchester Artificial Kidney Foundation
- Washington University George M. O'Brien Center [DK079333]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK052783, P30DK079333, R01DK054602, R01DK045462] Funding Source: NIH RePORTER
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The goals of this presentation are twofold: (1) to briefly sketch the field of vascular rarefaction as a key component of various fibrotic diseases and (2) to illustrate it with four vignettes depicting diverse mechanisms of microvascular rarefaction. Specifically, I shall describe migratory and angiogenic incompetence of endothelial cells under conditions of reduced bioavailability of nitric oxide, role of endothelial-to-mesenchymal cell and mesenchymal stem cell-to-endothelial reprogramming, and potential role of antiangiogenic peptides in the development of graft vascular disease as exemplified by chronic allograft nephropathy.
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