Journal
NUTRIENTS
Volume 6, Issue 8, Pages 3230-3244Publisher
MDPI
DOI: 10.3390/nu6083230
Keywords
advanced glycation end products (AGEs); lotus seedpod oligomeric procyanidins (LSOPC); metabolites; carbonyl; antioxidant
Categories
Funding
- HZAU [2013YB07]
- national Natural Science Foundation of China (NSFC) [31071633]
Ask authors/readers for more resources
Several lines of evidence suggested that B-type procyanidin oligomers from lotus seedpod (LSOPC) may effectively modulate the formation of advanced glycation end products (AGEs). In vivo, LSOPC is metabolized by intestinal flora to become various kinds of phenolic compounds that possess potent antioxidant activities. However, few reports of the absorption and metabolism of LSOPC have been revealed. In the present study, rats were orally administered with LSOPC at a dose of 300 mg/kg body weight. The metabolites of LSOPC in urine were elucidated by HPLC-MS/MS analysis 24 h post-administration. Eight major metabolites were significantly increased by the administration of 300 mg/kg of LSOPC (p < 0.01). The anti-glycative activity of LSOPC and its metabolites were investigated. The results showed that LSOPC and catechin had greater anti-glycative activities than other metabolites, which were positively correlated to their carbonyl scavenging activities and antioxidant capacities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available