Journal
NUTRIENTS
Volume 6, Issue 10, Pages 4178-4190Publisher
MDPI AG
DOI: 10.3390/nu6104178
Keywords
turmeric; curcumin; IL-10; inflammatory bowel disease; SLC22A4; OCTN1; nutrigenomics
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Funding
- Ministry of Business, Innovation and Employment (New Zealand)
- Ministry of Business, Innovation and Employment (MBIE) [C11X1009, CO2X0403]
- New Zealand Ministry of Business, Innovation & Employment (MBIE) [C11X1009] Funding Source: New Zealand Ministry of Business, Innovation & Employment (MBIE)
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Inflammatory bowel disease (IBD) is a chronic relapsing disease. Genetic predisposition to the disease reduces an individual's capacity to respond appropriately to environmental challenges in the intestine leading to inappropriate inflammation. IBD patients often modify their diet to mitigate or reduce the severity of inflammation. Turmeric (Curcuma longa L., Zingiberaceae) has historically been used in Chinese, Hindu, and Ayurvedic medicine over several centuries to treat inflammatory disorders. To understand how turmeric may influence the consequences of a genetic predisposition to inappropriate inflammation, we used HEK293 cells to examine the in vitro capacity of turmeric extract and fractions to affect the functionality of two gene variants, solute carrier protein 22 A4 (SLC22A4, rs1050152) and interleukin-10 (IL-10, rs1800896) associated with IBD. We found that a turmeric extract and several chromatographically separated fractions beneficially affected the variants of SLC22A4 and IL-10 associated with IBD, by reducing inappropriate epithelial cell transport (SLC22A4, 503F) and increasing anti-inflammatory cytokine gene promoter activity (IL-10, -1082A). The effect of turmeric on the IL-10 variant was strongly associated with the curcumin content of the extract and its fractions.
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