Journal
NUTRIENTS
Volume 5, Issue 2, Pages 543-551Publisher
MDPI AG
DOI: 10.3390/nu5020543
Keywords
lutein; docosahexaenoic acid; age-related macular degeneration; macular pigment density
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Funding
- Thea Laboratoires' Grant
- RETICS from ISCIII, Ministerio de Ciencia e Innovacion, Spain [RD07/0062]
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We studied the macular pigment ocular density (MPOD) in patients with early age macular degeneration (AMD) before and 1 year after nutritional supplementation with lutein and docosahexaenoic acid (DHA). Forty-four patients with AMD were randomly divided into two groups that received placebo (n = 21) or a nutritional supplement (n = 23, 12 mg of lutein and 280 mg of DHA daily). Heterochromatic flicker photometry was used to determine the MPOD. At baseline, the MPOD in AMD patients with placebo was 0.286 +/- 0.017 meanwhile in AMD patients with supplementation it was 0.291 +/- 0.016. One year later, the mean MPOD had increased by 0.059 in the placebo group and by 0.162 in patients receiving lutein and DHA. This difference between groups was significant (p < 0.05). Lutein and DHA supplementation is effective in increasing the MPOD and may aid in prevention of age related macular degeneration.
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