Journal
NUTRIENTS
Volume 5, Issue 11, Pages 4347-4363Publisher
MDPI
DOI: 10.3390/nu5114347
Keywords
tocopherols; lung disease; endothelial
Categories
Funding
- National Institutes of Health [HL069428, AT004837]
- American Heart Association [0855583G, 12GRNT12100020]
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Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Clinical studies suggest a number of protective dietary factors for asthma, including vitamin E. However, studies of vitamin E in allergy commonly result in seemingly conflicting outcomes. Recent work indicates that allergic inflammation is inhibited by supplementation with the purified natural vitamin E isoform -tocopherol but elevated by the isoform -tocopherol when administered at physiological tissue concentrations. In this review, we discuss opposing regulatory effects of -tocopherol and -tocopherol on allergic lung inflammation in clinical trials and in animal studies. A better understanding of the differential regulation of inflammation by isoforms of vitamin E provides a basis towards the design of clinical studies and diets that would effectively modulate inflammatory pathways in lung disease.
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