Journal
NUTRIENTS
Volume 2, Issue 3, Pages 241-279Publisher
MDPI
DOI: 10.3390/nu2030241
Keywords
isoflavones; PPAR alpha; PPAR gamma; AhR; inflammation; metabolic syndrome; atherosclerosis; cell cycle control; xenobiotic metabolism
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Isoflavones have multiple actions on cell functions. The most prominent one is the activation of estrogen receptors. Other functions are often overlooked, but are equally important and explain the beneficial health effects of isoflavones. Isoflavones are potent dual PPAR alpha/gamma agonists and exert anti-inflammatory activity, which may contribute to the prevention of metabolic syndrome, atherosclerosis and various other inflammatory diseases. Some isoflavones are potent aryl hydrocarbon receptor (AhR) agonists and induce cell cycle arrest, chemoprevention and modulate xenobiotic metabolism. This review discusses effects mediated by the activation of AhR and PPARs and casts a light on the concerted action of isoflavones.
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