Journal
NEUROPSYCHIATRIC DISEASE AND TREATMENT
Volume 10, Issue -, Pages 835-840Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S62741
Keywords
neurotrophins; depression; mania; bipolar disorder; acute phase; clinical sample
Categories
Funding
- SMC-Morningstar excellent young teachers (C plan) in Shanghai Jiao Tong University
- Shanghai Health Bureau [2009098]
- National Natural Science Foundation of China [81000588, 61102020, 81201043]
- Shanghai Health System Young Talents Training Plan in Shanghai Health Bureau [XYQ2011016]
- Shanghai Municipal Natural Science Foundation [12ZR1448400]
- National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH) [2011-873]
- Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine [BXJ 201345]
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Background: Nerve growth factor (NGF) has received much attention for its role in mood disorders. The primary objective of the present study was to examine serum NGF levels in Chinese inpatients with depressive or manic episodes in the acute phase and to explore the changes in NGF levels after effective clinical treatments. Methods: One hundred and seven consecutive inpatients and outpatients with mood disorders (30 with unipolar depression, 23 with bipolar depression, and 54 with bipolar mania), and 50 healthy controls were recruited. The serum NGF levels were detected by enzyme-linked immunosorbent assay. Results: Patients with bipolar mania presented higher serum NGF levels compared to those of healthy controls. After 8 weeks of medical treatment, there were significant improvements in symptoms in patients, but no significant changes in NGF levels. Conclusion: The present findings may help to strengthen and expand the understanding of the role of NGF in the acute stages of mood disorders.
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