Fabrication of Acid-Responsive Electrospun Fibers via Doping Sodium Bicarbonate for Quick Releasing Drug

Acid-responsive electrospun nanofibers are gaining considerable attention as highly versatile tools which offer responsive drug releasing carriers and tissue engineering scaffold. A feasible acid-responsive ibuprofen-loaded electrospun fibers was presented by introducing sodium bicarbonate (NaHCO3) into Poly(lactic-co-glycolic acid) via blend electrospinning. The acid-responsive electrospun fibers showed the uniform micro/nano fiber morphology and porous fibrous structures. In vitro release profiles showed that the ibuprofen release rates of fibers were significantly accelerated after incubation into pH 5.0 compared to pH 7.4 solutions. During the investigational period, almost no mass loss and weight reduction was detected. These acid-responsive electrospun fibers are promising as smart drug carriers for targeted drug delivery and tissue engineering scaffolds.