Journal
MYCOLOGICAL RESEARCH
Volume 113, Issue -, Pages 915-923Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mycres.2009.03.006
Keywords
Cell wall; Drug target; Histidine kinase; Polar growth; Promoter; RNA interference; Sporulation
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Funding
- National High Technology Research and Development Program of China (863)
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Penicillium marneffei is an important opportunistic dimorphic fungal pathogen that can cause fatal systemic mycosis in AIDS patients. To find new ways of overcoming infection, candidate virulence associated genes and virulence mechanisms are under intensive investigation. in the present study, we have examined the function of a novel P. marneffei histidine kinase gene (PmHHK1) using dsRNAi mediated by Agrobacterium tumefaciens. Our results showed that reduction of PmHHK1 expression produces significant changes in morphogenesis (including polarized growth), sporulation and cell wall composition. Two-component signaling systems are widespread in the eukaryotes outside the animal kingdom, and could be potential drug targets for antifungal chemotherapy. (C) 2009 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.
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