Journal
MATERIALS
Volume 3, Issue 7, Pages 4051-4065Publisher
MDPI
DOI: 10.3390/ma3074051
Keywords
multifunctional magnetic nanoparticles; chitosan; MnFe2O4 nanoparticles; magnetic hyperthermia; drug delivery
Categories
Funding
- University of Alabama
- Korea Research Foundation
- Korean Government (MOEHRD) [KRF-2006-D00092]
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Multifunctional nanoparticles composed of MnFe2O4 were encapsulated in chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe2O4 to be used as an efficient MRI contrast agent for cancer diagnosis. This paper focuses on the synthesis and characterization of magnetic MnFe2O4 nanoparticles, their dispersion in water and their incorporation in chitosan, which serves as a drug carrier. The surface of the MnFe2O4 nanoparticles was modified with meso-2,3-di-mercaptosuccinic acid (DMSA) to develop stable aqueous dispersions. The nanoparticles were coated with chitosan, and the magnetic properties, heat generation and hydrodynamic size of chitosan-coated MnFe2O4 were evaluated for various linker concentrations and in a range of pH conditions.
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