Journal
MATERIALS
Volume 2, Issue 4, Pages 1908-1922Publisher
MDPI AG
DOI: 10.3390/ma2041908
Keywords
spider silk; recombinant; biocompatibility; in vivo
Categories
Funding
- European Commission [G5RD-CT-2002-00738]
- Swedish Research Council
- Swedish Agency for Innovation Systems
- Formas
Ask authors/readers for more resources
Spider silk is an interesting biomaterial for medical applications. Recently, a method for production of recombinant spider silk protein (4RepCT) that forms macroscopic fibres in physiological solution was developed. Herein, 4RepCT and Mersilk(TM) (control) fibres were implanted subcutaneously in rats for seven days, without any negative systemic or local reactions. The tissue response, characterised by infiltration of macrophages and multinucleated cells, was similar with both fibres, while only the 4RepCT-fibres supported ingrowth of fibroblasts and newly formed capillaries. This in vivo study indicates that 4RepCT-fibres are well tolerated and could be used for medical applications, e. g., tissue engineering.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available