Journal
JALA
Volume 15, Issue 3, Pages 224-232Publisher
SAGE PUBLICATIONS INC
DOI: 10.1016/j.jala.2010.02.003
Keywords
BioMEMS; sample enrichment; cell separation; lab on a chip
Funding
- Institute for Critical Technology and Applied Science (ICTAS)
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A microfluidic system for the enrichment of biological particles, operating on the principle of dielectrophoresis (DEP), is presented. Through the use of a unique manifestation of DEP, contactless DEP (cDEP), this system illustrates the potential to sidestep the common trade-off between sample throughput and selectivity without the need of a complicated fabrication process. The ability to concentrate particles from a sample fluid is validated experimentally through the concentration of 2-mu m polystyrene beads and live THP-I human leukemia cells from a heterogeneous media solution. Finite element analysis of the electric field within the microfluidic channel of the device allows for the determination of effective experimental parameters and accurate predictions of a particle's trajectory through the device. The concentration of particles combined with a fabrication procedure conducive to mass production makes cDEP an attractive alternative to current sample enrichment technologies. (JALA 2010;15:224-32)
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