Journal
SCIENCE SIGNALING
Volume 8, Issue 368, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.2005813
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Funding
- National Cancer Institute [R01, R21, R01 CA139067, 1R21CA175560-01]
- California Institute for Regenerative Medicine New Faculty Award [RN2-00923-1]
- Tobacco-Related Disease Research Program research grant [21RT-0133]
- research scholar award from the American Cancer Society (ACS) [123339-RSG-12-265-01-RMC]
- Leukemia and Lymphoma Society special fellow award (LLS) [3423-3513]
- NIH [R01, R01HL098608]
- National Heart, Lung, and Blood Institute [R01, R01HL098608]
- NATIONAL CANCER INSTITUTE [R21CA175560, R00CA126186, R01CA139067] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL098608] Funding Source: NIH RePORTER
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MicroRNAs (miRNAs) comprise a class of small, regulatory noncoding RNAs (ncRNAs) with pivotal roles in posttranscriptional gene regulation. Since their initial discovery in 1993, numerous miRNAs have been identified in mammalian genomes, many of which play important roles in diverse cellular processes in development and disease. These small ncRNAs regulate the expression of many protein-coding genes posttranscriptionally, thus adding a substantial complexity to the molecular networks underlying physiological development and disease. In part, this complexity arises from the distinct gene structures, the extensive genomic redundancy, and the complex regulation of the expression and biogenesis of miRNAs. These characteristics contribute to the functional robustness and versatility of miRNAs and provide important clues to the functional significance of these small ncRNAs. The unique structure and function of miRNAs will continue to inspire many to explore the vast noncoding genome and to elucidate the molecular basis for the functional complexity of mammalian genomes.
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